A Direct Approach to the Synthesis of Famciclovir and Penciclovir
- 1 May 1996
- journal article
- research article
- Published by Informa UK Limited in Nucleosides and Nucleotides
- Vol. 15 (5), 981-994
- https://doi.org/10.1080/07328319608002029
Abstract
Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1-tricarboxylate followed by decarbethoxylation/transesterification of the unpurified product was the key sequence in synthesising both the anti-herpesvirus agent penciclovir and its oral from famciclovir in three isolated steps.Keywords
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