Local RNA Target Structure Influences siRNA Efficacy: Systematic Analysis of Intentionally Designed Binding Regions
- 13 May 2005
- journal article
- Published by Elsevier BV in Journal of Molecular Biology
- Vol. 348 (4), 883-893
- https://doi.org/10.1016/j.jmb.2005.03.011
Abstract
No abstract availableKeywords
This publication has 43 references indexed in Scilit:
- Improving the efficiency of RNA interference in mammalsNature Reviews Genetics, 2004
- siRNAs: applications in functional genomics and potential as therapeuticsNature Reviews Drug Discovery, 2004
- Therapeutic siRNAsTrends in Pharmacological Sciences, 2004
- Functional siRNAs and miRNAs Exhibit Strand BiasCell, 2003
- Gene Silencing by Systemic Delivery of Synthetic siRNAs in Adult MiceJournal of Molecular Biology, 2003
- Gene Silencing Mediated by Small Interfering RNAs in Mammalian CellsCurrent Medicinal Chemistry, 2003
- Analysis of gene function in somatic mammalian cells using small interfering RNAsMethods, 2002
- Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysateThe EMBO Journal, 2001
- Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsNature, 2001
- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansNature, 1998