Population pharmacokinetics of exogenous biotin and the relationship between biotin serum levels and in vitro immunoassay interference
Open Access
- 1 November 2017
- journal article
- Published by Future Science Ltd in International Journal of Pharmacokinetics
- Vol. 2 (4), 247-256
- https://doi.org/10.4155/ipk-2017-0013
Abstract
Aim: Biotin in human serum is a potential interfering factor for streptavidin-biotin-based assays. We aimed to evaluate the effective half-life of biotin and biotin metabolites, and establish a pharmacokinetic (PK) model to simulate the time taken for the biotin concentration to fall below a series of thresholds. Materials & methods: PK properties of biotin (5, 10 and 20 mg daily) were evaluated in healthy participants. Biotin serum concentrations were simulated for high-dose regimens (1 mg daily to 300 mg q.i.d.) using a population PK model. Results: Washout periods required for biotin concentrations to reach thresholds ranging from 10 to 100 ng/ml were successfully simulated. Conclusion: Our simulations provide valuable guidance on biotin washout periods necessary to avoid false assay results.Keywords
This publication has 12 references indexed in Scilit:
- Biotin Interference with Routine Clinical Immunoassays: Understand the Causes and Mitigate the RisksEndocrine Practice, 2017
- False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: the problem of biotin intake and related interferencescclm, 2017
- MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled studyMultiple Sclerosis Journal, 2016
- Serum biotin levels in women complaining of hair lossInternational Journal of Trichology, 2016
- Biotin treatment causing erroneous immunoassay results: A word of caution for cliniciansDrug Discoveries & Therapeutics, 2016
- Interference From Anti-Streptavidin AntibodyArchives of Pathology & Laboratory Medicine, 2013
- Positive and negative interference in immunoassays following biotin ingestion: a pharmacokinetic studyPathology, 2012
- Biotin interference on TSH and free thyroid hormone measurementPathology, 2012
- Biotin levels in plasma and urine of healthy adults consuming physiological doses of biotinNutrition Research, 1988
- Serum Biotin Levels in Patients Undergoing Chronic HemodialysisNephron, 1987