Tubulointerstitial injury and loss of nitric oxide synthases parallel the development of hypertension in the Dahl-SS Rat
- 1 October 2000
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal Of Hypertension
- Vol. 18 (10), 1497-1505
- https://doi.org/10.1097/00004872-200018100-00019
Abstract
Alterations in renal nitric oxide (NO) are involved in the hypertension of the Dahl salt-sensitive (Dahl-SS) rat. We sought to identify the kinetics and sites of expression of the major NO synthase (NOS) isoforms. The renal expression of the major NOS were examined in Dahl-SS and salt-resistant rats (Dahl-SR) while on a low salt (0.1% NaCl) diet at 3 and 9 weeks of age. Renal biopsies from Dahl-SS and Dahl-SR rats were compared for evidence of renal injury and for alterations in expression of the NOS enzymes by quantitative immunohistochemistry. At 3 weeks of age Dahl-SS and Dahl-SR rats have normal renal histology and similar immunohistochemical expression of NOS1, −2, and −3. At 9 weeks Dahl-SS rats had significantly higher blood pressure than Dahl-SR rats (P P Tubulointerstitial injury and the loss of NOS occur after birth and parallel the development of hypertension. We suggest that the structural and functional changes that occur with renal injury in the Dahl-SS rat may contribute to the development of hypertension.Keywords
This publication has 26 references indexed in Scilit:
- Reduced tolerance to acute renal ischemia in mice with a targeted disruption of the osteopontin geneKidney International, 1999
- Renal Intramedullary Infusion of l -Arginine Prevents Reduction of Medullary Blood Flow and Hypertension in Dahl Salt-Sensitive RatsHypertension, 1999
- Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide BlockadeHypertension, 1996
- Nitric Oxide Synthase Isoform Activities in Kidney of Dahl Salt-Sensitive RatsHypertension, 1995
- L-arginine administration normalizes pressure natriuresis in hypertensive Dahl rats.Hypertension, 1993
- Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats.Hypertension, 1993
- Impaired renal vascular reactivity in prehypertensive Dahl salt-sensitive rats.Hypertension, 1992
- Enhanced chloride reabsorption in the loop of Henle in Dahl salt-sensitive rats.Hypertension, 1991
- Renal disease and the development of hypertension in salt-sensitive Dahl ratsKidney International, 1988
- Dahl salt-susceptible and salt-resistant rats. A review.Hypertension, 1982