A Library of Multifunctional Polyesters with “Peptide-Like” Pendant Functional Groups
- 2 July 2013
- journal article
- research article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 14 (8), 2489-2493
- https://doi.org/10.1021/bm400697u
Abstract
The synthesis and characterization of a library of modular multifunctional polyesters with pendant functional groups are described. The polyesters were synthesized at room temperature by carbodiimide-mediated polymerization of pendant functionalized diols and succinic acid. The pendant groups are designed to mimic the side chains of peptides, and it is shown that the physical properties of the polyesters can be modulated over a wide range by the choice of pendant groups. We also show that the pendant groups can be orthogonally functionalized with ligands such as fluorophores, poly(ethylene glycol) (PEG) or Arg-Gly-Asp (RGD).Keywords
This publication has 55 references indexed in Scilit:
- Efficient synthesis of multifunctional polymers via thiol–epoxy “click” chemistryChemical Communications, 2012
- Core-Clickable PEG-Branch-Azide Bivalent-Bottle-Brush Polymers by ROMP: Grafting-Through and Clicking-ToJournal of the American Chemical Society, 2010
- Inspiration and application in the evolution of biomaterialsNature, 2009
- Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft MaterialsChemical Reviews, 2009
- Polymeric Biomaterials in Tissue EngineeringPediatric Research, 2008
- Smart materials as scaffolds for tissue engineeringJournal of Cellular Physiology, 2005
- Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineeringNature Biotechnology, 2005
- Biomaterials: Where We Have Been and Where We Are GoingAnnual Review of Biomedical Engineering, 2004
- Emerging Design Principles in Biomaterials and Scaffolds for Tissue EngineeringAnnals of the New York Academy of Sciences, 2002
- Third-Generation Biomedical MaterialsScience, 2002