Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke
- 5 February 2015
- journal article
- Published by Springer Science and Business Media LLC in Neurological Sciences
- Vol. 36 (6), 913-920
- https://doi.org/10.1007/s10072-015-2096-2
Abstract
To investigate the temporal expressions of IL-9 and its related cytokines after middle cerebral artery occlusion in rats. IL-9 and its related cytokines in ischemia brain and blood were tested after rats were subjected to transient focal ischemia. Comparing with sham-operated group, the levels of IL-4, TGF-β, PU.1, IRF4, OX40, NIK, RelB-p52 and IL-9 in experimental groups were significantly higher after middle cerebral artery occlusion. The results showed that expressions of IL-9 and its upstream stimulating factors increased in experimental stroke, and whether they play a role or just a secondary change is awaiting further research.Keywords
This publication has 27 references indexed in Scilit:
- Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental strokeEuropean Journal of Pharmacology, 2013
- Stroke and Stroke Care in ChinaStroke, 2011
- Regulating Il9 transcription in T helper cellsTrends in Immunology, 2011
- Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volumeZeitschrift für Neurologie, 2011
- The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammationNature Immunology, 2010
- Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytesJournal of Allergy and Clinical Immunology, 2003
- Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brainNeuroReport, 1998
- Tumor Necrosis Factor-αStroke, 1997
- Infarct Measurement MethodologyJournal of Cerebral Blood Flow & Metabolism, 1994
- Reversible middle cerebral artery occlusion without craniectomy in rats.Stroke, 1989