A Role forCaenorhabditis elegansChromatin-Associated Protein HIM-17 in the Proliferationvs. Meiotic Entry Decision
- 1 April 2007
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 175 (4), 2029-2037
- https://doi.org/10.1534/genetics.107.070987
Abstract
Chromatin-associated protein HIM-17 was previously shown to function in the chromosomal events of meiotic prophase. Here we report an additional role for HIM-17 in regulating the balance between germ cell proliferation and meiotic development. A cryptic function for HIM-17 in promoting meiotic entry and/or inhibiting proliferation was revealed by defects in germline organization in him-17 mutants grown at high temperature (25°) and by a synthetic tumorous germline phenotype in glp-1(ar202); him-17 mutants at 15°.Keywords
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