INCREASED APOPTOSIS IN THE CONTRALATERAL TESTES OF PATIENTS WITH TESTICULAR TORSION AS A FACTOR FOR INFERTILITY
- 1 September 1998
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 160 (3 Part 2), 1158-1160
- https://doi.org/10.1016/s0022-5347(01)62725-3
Abstract
Conclusions Extensive apoptosis is a phenomenon that occurs regularly in the germinal epithelium of the contralateral testis in testicular torsion. Specifically primary and secondary spermatocytes are predominantly affected. Notably spermatogonia, capillary endothelium, connective tissue and peritubular fibroblasts are rarely involved. A selection strategy has seemingly evolved that precludes the possibility of the perpetuation of genetic mutations. We hypothesize that trauma to the blood-testis barrier initiated by testicular torsion induces the release of apoptotic activating factors (cytokines), which subsequently cause extensive apoptosis in the germinal epithelium of the contralateral testis. Therefore, it is probable that repeat apoptotic episodes may explain the high incidence of infertility in these patients.Keywords
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