Contribution of Vascular Risk Factors to the Progression in Alzheimer Disease
- 1 March 2009
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 66 (3), 343-348
- https://doi.org/10.1001/archneur.66.3.343
Abstract
Few treatment options are available to improve the prognosis in patients with Alzheimer disease (AD). Controlling vascular conditions may be one way of delaying the disease course. Vascular risk factors and vascular disease are associated with higher risk of vascular dementia1,2 and AD.3,4 Members of our group previously reported associations between stroke,5 hyperinsulinemia,6 diabetes mellitus,7 current smoking,8 and hypertension9 and higher risk of AD. We found that high total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations are related to increased risk of vascular dementia10,11 but not AD.Keywords
This publication has 31 references indexed in Scilit:
- APOE ε4 allele predicts faster cognitive decline in mild Alzheimer diseaseNeurology, 2008
- Relation of Plasma Lipids to Alzheimer Disease and Vascular DementiaArchives of Neurology, 2004
- Stroke and the Risk of Alzheimer DiseaseArchives of Neurology, 2003
- The Role of Cerebrovascular Disease in DementiaThe Neurologist, 2003
- Statistical Analysis of Correlated Data Using Generalized Estimating Equations: An OrientationAmerican Journal of Epidemiology, 2003
- The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive functionNeurology, 2002
- Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related PathologiesDiabetes, 2002
- Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic CohortAmerican Journal of Epidemiology, 2001
- Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neuronsNeuroscience, 2000
- Vascular risk factors for Alzheimer’s disease:: An epidemiologic perspectiveNeurobiology of Aging, 2000