The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury
- 1 September 1989
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 71 (3), 403-416
- https://doi.org/10.3171/jns.1989.71.3.0403
Abstract
✓ There is evidence that posttraumatic ischemia is important in the pathogenesis of acute spinal cord injury (SCI). In the present study spinal cord blood flow (SCBF), measured by the hydrogen clearance technique, and motor and somatosensory evoked potentials (MEP and SSEP) were recorded to evaluate whether the administration of nimodipine and dextran 40, alone or in combination, could increase posttraumatic SCBF and improve axonal function in the cord after acute SCI. Thirty rats received a 53-gm clip compression injury on the cord at T-1 and were then randomly and blindly allocated to one of six treatment groups (five rats in each). Each group was given an intravenous infusion of one of the following over 1 hour, commencing 1 hour after SCI: placebo and saline; placebo and dextran 40; nimodipine 0.02 mg/kg and saline; nimodipine 0.02 mg/kg and dextran 40; nimodipine 0.05 mg/kg and saline; and nimodipine 0.05 mg/kg and dextran 40. The preinjury physiological parameters, including the SCBF at T-1 (mean ± ...Keywords
This publication has 43 references indexed in Scilit:
- The effect of direct-current field on recovery from experimental spinal cord injuryJournal of Neurosurgery, 1988
- Motor and somatosensory evoked potentials recorded from the ratElectroencephalography and Clinical Neurophysiology, 1988
- Motor evoked potentials recorded from normal and spinal cord-injured ratsNeurosurgery, 1987
- Calcium and Ischemic InjuryNew England Journal of Medicine, 1986
- Failure of Nimodipine to Reverse Acute Experimental Spinal Cord InjuryCentral Nervous System Trauma, 1985
- Evaluation of the calcium channel antagonist nimodipine in experimental spinal cord ischemiaJournal of Neurosurgery, 1984
- A review and update of experiment and clinical studies of spinal cord injurySpinal Cord, 1983
- The role of calcium in cell deathLife Sciences, 1981
- Microangiographic observations of the experimentally traumatized spinal cordJournal of Neurosurgery, 1971
- Microangiographic study of experimental spinal cord injuriesJournal of Neurosurgery, 1971