Late Aortic Root Dilatation in Tetralogy of Fallot may be Prevented by Early Repair in Infancy
- 30 July 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Pediatric Cardiology
- Vol. 25 (6), 654-659
- https://doi.org/10.1007/s00246-003-0665-2
Abstract
The objectives of this study were to examine the relative contributions of development and hemodynamics in aortic root dilatation of tetralogy of Fallot, to assess the impact of systemic to pulmonary artery shunt on aortic annular size, and to seek any relationship between the timing of corrective surgery and subsequent aortic root size. We performed a retrospective analytical study at a tertiary referral center of M-mode and two-dimensionol aortic root measurements in children with tetralogy of Fallot prior to any surgical or palliative intervention, after insertion of a surgical shunt, and on intermediate and long-term follow-up post-repair. The main outcome measures were aortic root diameter prior to correction, after palliative shunt insertion, and after definitive repair. The study found that the aortic root is enlarged in unrepaired tetralogy of Fallot irrespective of age, increased in the first 3–6 months after palliative shunt surgery, and persisted into adulthood in those repaired after 1 year of age. Age-corrected aortic root dimensions normalized by midchildhood in those who were repaired in infancy. Preexisting aortic root dilatation normalizes by 7 years of age in patients with tetralogy of Fallot who have been repaired in infancy, whereas it persists into adulthood in the group repaired postinfancy.Keywords
This publication has 17 references indexed in Scilit:
- Progressive Aortic Root Dilatation in Adults Late After Repair of Tetralogy of FallotCirculation, 2002
- Aortic valve replacement after repair of pulmonary atresia and ventricular septal defect or tetralogy of fallotThe Journal of Thoracic and Cardiovascular Surgery, 1997
- New perspectives in the assessment of cardiac chamber dimensions during development and adulthoodJournal of the American College of Cardiology, 1992
- The aetiology and course of isolated severe aortic regurgitation: a clinical, pathological, and echocardiographic study.Heart, 1987
- Tetralogy of Fallot Associated with Aortic InsufficiencyThe Annals of Thoracic Surgery, 1980
- The floppy mitral valve. Study of incidence, pathology, and complications in surgical, necropsy, and forensic material.Heart, 1978
- Postoperative Studies in Patients with Tetralogy of FallotThe Annals of Thoracic Surgery, 1975
- Malformations of the aortic valve in patients with the tetralogy of FallotAmerican Heart Journal, 1968
- Anatomic types of ventricular septal defect with aortic insufficiency: Diagnostic and surgical considerationsAmerican Heart Journal, 1968
- Cardiovascular anomalies associated with tetralogy of fallotThe American Journal of Cardiology, 1967