Sex-related variations in cortical and trabecular bone of the femoral neck in an elderly Chinese population
- 12 April 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in Osteoporosis International
- Vol. 28 (8), 2391-2399
- https://doi.org/10.1007/s00198-017-4043-y
Abstract
Summary Quantitative computed tomography (QCT) was used to investigate sex-related variations in cortical and trabecular bone of the femoral neck. Cortical bone thickness of women in the superior quadrant was thinner than that of men, and the cortex in all four quadrants was negatively associated with age in women. Introduction This cross-sectional study aimed to investigate sex-related similarities and differences in femoral neck structure in an elderly Chinese population by QCT bone investigational toolkit (BIT) analysis. Methods This study included 207 male (67.9 ± 7.7 years; range, 55–87 years) and 400 female subjects (68.0 ± 8.7 years; range, 55–96 years). BIT module was used to measure cortical and trabecular bone in anatomic quadrants of the femoral neck. Measurements of cortical thickness (Ct.Th), cortical vBMD (Ct.vBMD), trabecular vBMD (Tb.vBMD), and integral vBMD (It.vBMD) at the femoral neck were determined in four anatomical sectors. Results The greatest difference between sexes, after adjusting for age, height, and weight, was in Ct.Th of Quadrant Supero-anterior (SA), which was 27.4% lower in women (pp = 0.027). Ct.Th and Tb.vBMD in all four quadrants appeared to be negatively associated with age in females, whereas no significant relationship was observed in males, except Ct.Th of Quadrant SP. Conclusions The superior femoral neck geometry between males and females was significantly different, even after adjustment for body size and age, and the sub-regional cortical and trabecular bone negatively age-related changes in women indicated that women apparently have a more vulnerable geometrical outcome with age for fractures than men.Keywords
Funding Information
- National Natural Science Foundation of China (81071131)
- Beijing Bureauof Health 215 program (2009-2-03, 2013-3-033)
- Capital Characteristic Clinic Project (Z141107002514072)
This publication has 26 references indexed in Scilit:
- Relationship of femoral neck areal bone mineral density to volumetric bone mineral density, bone size, and femoral strength in men and womenOsteoporosis International, 2011
- Phantom-less QCT BMD system as screening tool for osteoporosis without additional radiationEuropean Journal of Radiology, 2011
- Rapidly increasing rates of hip fracture in Beijing, ChinaJournal of Bone and Mineral Research, 2011
- Distribution of cortical bone in the femoral neck and hip fracture: A prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK StudyBone, 2011
- Secular trends in the incidence of hip and other osteoporotic fracturesOsteoporosis International, 2011
- Effects of age and sex on the strength and cortical thickness of the femoral neckBone, 2011
- In vivo discrimination of hip fracture with quantitative computed tomography: Results from the prospective European Femur Fracture Study (EFFECT)Journal of Bone and Mineral Research, 2010
- Age-dependence of femoral strength in white women and menJournal of Bone and Mineral Research, 2010
- Changing structure of the femoral neck across the adult female lifespanJournal of Bone and Mineral Research, 2010
- Accurate assessment of precision errors: How to measure the reproducibility of bone densitometry techniquesOsteoporosis International, 1995