VITAMIN D IN HEALTH AND DISEASE: The Role of Vitamin D in Vascular Calcification in Chronic Kidney Disease
- 19 July 2005
- journal article
- review article
- Published by Wiley in Seminars in Dialysis
- Vol. 18 (4), 307-314
- https://doi.org/10.1111/j.1525-139x.2005.18407.x
Abstract
Vascular calcification is a significant cause of morbidity and mortality in patients with chronic kidney disease (CKD). Disorders of mineral metabolism are likely involved in the pathogenesis of vascular calcification. Calcitriol and its analogs are effective in suppressing parathyroid hormone levels in patients with secondary hyperparathyroidism and CKD, but experimental studies demonstrate that these drugs can act directly on vascular smooth muscle cells. In some in vitro studies and in animal models of CKD, calcitriol has induced vascular calcification. Newer analogs of vitamin D appear to be less likely to induce vascular calcification, although published data are scarce. However, there is really no clear evidence in dialysis patients that calcitriol or analog administration is directly responsible for the induction of vascular calcification. However, indirectly, by oversuppression of parathyroid hormone (PTH) and induction of a low-turnover bone disease state, or by increased calcium-phosphorus product, the administration of calcitriol or its analogs may contribute to vascular calcification in patients with CKD. However, prospective randomized trials in CKD patients are necessary to fully understand the impact of calcitriol and analog therapy on vascular calcification.Keywords
This publication has 100 references indexed in Scilit:
- Natural history of vascular calcification in dialysis and transplant patientsNephrology Dialysis Transplantation, 2004
- Pulse Pressure Is an Independent Predictor for the Progression of Aortic Wall Calcification in Patients With Controlled HyperlipidemiaHypertension, 2004
- Arterial Calcifications, Arterial Stiffness, and Cardiovascular Risk in End-Stage Renal DiseaseHypertension, 2001
- Atherosclerotic cardiovascular disease risks in chronic hemodialysis patientsKidney International, 2000
- Effect of degenerative spinal and aortic calcification on bone density measurements in post‐menopausal women: links between osteoporosis and cardiovascular disease?European Journal of Clinical Investigation, 1994
- High expression of genes for calcification-regulating proteins in human atherosclerotic plaques.JCI Insight, 1994
- Production and characterization of antibodies to advanced glycation products on proteinsBiochemical and Biophysical Research Communications, 1989
- 1,25-Dihydroxyvitamin D3 and rat vascular smooth muscle cell growth.Hypertension, 1989
- 1,25-dihydroxyvitamin D3 stimulates 45Ca2+-uptake by cultured vascular smooth muscle cells derived from rat aortaBiochemical and Biophysical Research Communications, 1988
- UREMIC ARTERIAL DISEASE IN RABBITS WITH SPECIAL REFERENCE TO THE CORONARY ARTERIESActa Pathologica Microbiologica Scandinavica Series A :Pathology, 1985