Mucosal Leishmaniasis: An Underestimated Presentation of a Neglected Disease
Open Access
- 18 June 2013
- journal article
- review article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2013, 1-7
- https://doi.org/10.1155/2013/805108
Abstract
We present a review of current knowledge about mucosal leishmaniasis (ML). Although involvement of mucous membranes is classically admitted in New World leishmaniasis, particularly occurring in infection byLeishmania (L.) braziliensisspecies complex, ML is also a possible presentation of Old World leishmaniasis, in eitherL. donovaniorL. majorspecies complex infections. Thus, ML has to be considered not only as a Latin American disease but as an Old and New World disease. We describe ML epidemiology, pathogenesis, clinics, diagnosis, and therapy. Considering both its highly disfiguring lesions and its possible lethal outcome, ML should not be underestimated by physicians. Moreover, leishmaniasis is expected to increase its burden in many countries as sandfly vector distribution is widespreading towards non-endemic areas. Finally, the lack of clear understanding of ML pathogenesis and the absence of effective human vaccines strongly claim for more research.This publication has 51 references indexed in Scilit:
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