Determination of callus quantity in 4‐ week‐old fractures of the rat tibia
- 1 January 1985
- journal article
- research article
- Published by Wiley in Journal of Orthopaedic Research
- Vol. 3 (1), 101-108
- https://doi.org/10.1002/jor.1100030113
Abstract
In clinical practice the quantity of fracture callus is usually estimated on the basis of radiographs. In experimental studies on fracture healing, more exact chemical measurements (total protein, DNA, and mineral contents) have been used to quantitate the amount of callus. It is not known, however, how these two parameters correlate with each other. In this study we used different (radiographic, histomorphometric, and chemical) methods to evaluate the quantity of fracture callus in 4‐week‐old tibial fractures of rats stabilized by intramedullary nailing. The wet and dry weights and the nitrogen, collagen, calcium, phosphorus, and DNA contents of the calluses showed no correlation with the radiographic size of the calluses. There was a strong correlation (p < 0.001), however, between radiographic and histomorphometric callus sizes. The mass of callus and the chemically defined parameters of callus production thus indicate different properties of the healing bone.Keywords
This publication has 12 references indexed in Scilit:
- Fracture Healing After Rigid Intramedullary Nailing in RatsActa Orthopaedica, 1983
- Modification of fracture repair with selected pulsing electromagnetic fields.The Journal of Bone & Joint Surgery, 1982
- Effect of Instability on Experimental Fracture HealingActa Orthopaedica, 1982
- Studies on the Mechanism of Callus Cartilage Differentiation and Calcification During Fracture HealingOrthopedic Clinics of North America, 1978
- FRACTURE HEALING IN THE SCIATICALLY DENERVATED RATJournal Of Trauma-Injury Infection and Critical Care, 1977
- Fracture healing in rat femora as affected by functional weight-bearingThe Journal of Bone & Joint Surgery, 1977
- A method for the production of an undisplaced reproducible tibial fracture in the ratInjury, 1977
- The Effect of Reduced Barometric Pressure on Fracture Healing in RatsThe Journal of Bone & Joint Surgery, 1967
- The Repair of Experimental Fractures During Long-Term Anticoagulant Treatment :An Experimental Study On RatsActa Orthopaedica, 1965