Effects of Perhexiline on Coronary Hemodynamic and Myocardial Metabolic Responses to Tachycardia
- 1 May 1974
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 49 (5), 887-893
- https://doi.org/10.1161/01.cir.49.5.887
Abstract
Coronary hemodynamic and myocardial metabolic responses before and after perhexiline administration were studied in 21 patients with coronary heart disease during pacing-induced angina pectoris. Perhexiline increased the threshold to tachycardia-induced angina pectoris in 16 of the 21 patients (HR 123 ± 3 to 134 ± 3 beats/min, P < 0.01). Anaerobic myocardial lactate extraction was reduced by –6.1 ± 6.3 to 10.7 ± 4% after perhexiline, although lactate extraction declined in four patients and ST segment depression was not significantly changed. Myocardial oxygen extraction was enhanced, 64 ± 2 to 69 ± 2% (P < 0.05). Coronary flow as reflected by coronary sinus blood flow was not altered (165 ± 24 to 173 ± 26 cc/min) as left ventricular oxygen utilization was increased (18.9 ± 4 to 20.9 ± 4 ml/min, P < 0.05). These findings are interpreted to indicate decreased myocardial ischemia in certain patients on perhexiline.Keywords
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