Reward processing in autism
- 31 March 2010
- journal article
- research article
- Published by Wiley in Autism Research
- Vol. 3 (2), 53-67
- https://doi.org/10.1002/aur.122
Abstract
The social motivation hypothesis of autism posits that infants with autism do not experience social stimuli as rewarding, thereby leading to a cascade of potentially negative consequences for later development. While possible downstream effects of this hypothesis such as altered face and voice processing have been examined, there has not been a direct investigation of social reward processing in autism. Here we use functional magnetic resonance imaging to examine social and monetary rewarded implicit learning in children with and without autism spectrum disorders (ASD). Sixteen males with ASD and sixteen age‐ and IQ‐matched typically developing (TD) males were scanned while performing two versions of a rewarded implicit learning task. In addition to examining responses to reward, we investigated the neural circuitry supporting rewarded learning and the relationship between these factors and social development. We found diminished neural responses to both social and monetary rewards in ASD, with a pronounced reduction in response to social rewards (SR). Children with ASD also demonstrated a further deficit in frontostriatal response during social, but not monetary, rewarded learning. Moreover, we show a relationship between ventral striatum activity and social reciprocity in TD children. Together, these data support the hypothesis that children with ASD have diminished neural responses to SR, and that this deficit relates to social learning impairments.Keywords
This publication has 60 references indexed in Scilit:
- Anticipation of monetary and social reward differently activates mesolimbic brain structures in men and womenSocial Cognitive and Affective Neuroscience, 2009
- Basal ganglia and dopamine contributions to probabilistic category learningNeuroscience & Biobehavioral Reviews, 2008
- Dissociating the Role of the Orbitofrontal Cortex and the Striatum in the Computation of Goal Values and Prediction ErrorsJournal of Neuroscience, 2008
- Social cognitionPhilosophical Transactions B, 2008
- Marketing actions can modulate neural representations of experienced pleasantnessProceedings of the National Academy of Sciences of the United States of America, 2008
- Neural correlates of reward in autismThe British Journal of Psychiatry, 2008
- Atypical involvement of frontostriatal systems during sensorimotor control in autismPsychiatry Research: Neuroimaging, 2007
- Anatomy and neurochemistry of the pair bondJournal of Comparative Neurology, 2005
- Neuroanatomical and neurocognitive differences in a pair of monozygous twins discordant for strictly defined autismAnnals of Neurology, 1998
- Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size ThresholdMagnetic Resonance in Medicine, 1995