Nipple involvement and multicentricity in breast cancer
- 1 August 1987
- journal article
- research article
- Published by Springer Science and Business Media LLC in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 113 (5), 481-487
- https://doi.org/10.1007/bf00390043
Abstract
Our study examined 166 patients with breast cancer with a mean age of 63 years. Each patient underwent mastectomy with the organ being investigated by histological giant sections and additional small sections from the nipple. Nipple involvement was found in 64 cases (38%). Multifocal carcinoma occurred in 76 patients. Further multicentric carcinomatous foci (36 cases) demonstrated a significant increase in affected nipples. Additional atypical ductal or lobular hyperplasia was observed in 53 cases and showed involvement in 34. Nine carcinomas of ductal origin were combined with lobular carcinoma in situ, all cases proved to have carcinomatous changes in the nipple. It is concluded that apart from the well-known influence of advanced tumor stages and tumor localization, nipple involvement correlates with multicentricity and multifocality of breast cancer as a disease of the whole organ.Keywords
This publication has 18 references indexed in Scilit:
- Five-Year Results of a Randomized Clinical Trial Comparing Total Mastectomy and Segmental Mastectomy with or without Radiation in the Treatment of Breast CancerNew England Journal of Medicine, 1985
- Histological Study on Multicentricity of Breast Carcinoma by Means of Whole-Organ SectionsPublished by Springer Science and Business Media LLC ,1985
- Zur Frage der Beteiligung der Mamille beim MammakarzinomGeburtshilfe und Frauenheilkunde, 1983
- Involvement of the Nipple and Areola in Breast Cancer: Value of Clinical FindingsScandinavian Journal of Plastic and Reconstructive Surgery, 1981
- Neoplastic involvement of nipple and skin flap in carcinoma of the breastThe American Journal of Surgical Pathology, 1980
- Zur Bedeutung der Mamille beim Brustdrüsenkrebs der FrauGeburtshilfe und Frauenheilkunde, 1980
- Spread to the Nipple and Areola in Carcinoma of the BreastAnnals of Surgery, 1979
- The case against tylectomy for carcinoma of the breast: The factor of multicentricityThe American Journal of Surgery, 1975
- Breast reconstruction: A plea for saving the uninvolved nippleThe American Journal of Surgery, 1971
- Further observations on Paget's disease of the nippleThe Journal of Pathology and Bacteriology, 1939