Phagosomal acidification: measurement, manipulation and functional consequences
- 25 October 2007
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 35 (5), 1083-1087
- https://doi.org/10.1042/bst0351083
Abstract
Phagocytosis holds a central position in the development of a successful innate immune response and in the initiation of the corresponding adaptive response. The destruction of invading pathogens and the presentation of their antigens to lymphoid cells require acidification of the phagosomal lumen. The present review discusses the mechanism of phagosome acidification, with particular reference to the two components of the protonmotive force: the chemical (pH) gradient and the electrical potential across the phagosomal membrane. A method for the in situ measurement of the electrical potential across the phagosomal membrane is described. In addition, we discuss the finding that acidification is not only a consequence, but also a critical determinant of phagosome maturation. Luminal acidification appears to function as a timing device controlling the transition between early and late phagosomes.This publication has 20 references indexed in Scilit:
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