Immunoglobulin V Gene Expression in CD5 B‐Cell Malignanciesa
- 1 May 1992
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 651 (1), 373-383
- https://doi.org/10.1111/j.1749-6632.1992.tb24638.x
Abstract
Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphomas (SLL) generally are malignancies of CD5 B cells. Immunophenotypic and clinicopathologic data, however, are required to distinguish subtypes that apparently have a different cytogenesis than that of conventional CLL or SLL. In addition to expressing CD5, neoplastic cells of the latter are also distinctive in that they frequently coexpress surface immunoglobulin (Ig), bearing one or more cross-reactive idiotypes (CRIs) (e.g. 17.109, G6,) that commonly are found on monoclonal IgM autoantibodies. The frequent occurrence of such CRIs reflects both the biased rearrangement and subsequent selected expression of Ig V genes with little or no somatic mutation. IgM/L CLL, for example, frequently (8/33) harbor abortive Ig rearrangements involving Humkv325, the VK gene encoding the 17.109-CRI. Also, the VH1 gene(s) encoding the G6 CRI accounts for over 10% of all VH genes and over 60% of all the VH1 genes used in randomly selected common CLL/SLL. Furthermore, comparison with the Ig expressed by nonmalignant G6 CRI+ B cells reveals an apparent restriction in the CDR3 of IgH expressed by G6 CRI+ CLL. Coupled with the observed potential bias in antibody light chain and heavy chain pairing in B-CLL, these data suggest that the autoantibodies expressed in this disease are selected based on antigen-binding activity. Collectively, our studies indicate that nonstochastic Ig V gene rearrangement and subsequent selection may influence the Ig repertoire expressed in this common B-cell malignancy.Keywords
This publication has 71 references indexed in Scilit:
- Phenotypic heterogeneity of B- and T-cell differentiation antigens in B-CLLEuropean Journal of Haematology, 2009
- Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunizationInternational Immunology, 1990
- The Human Immunoglobulin ϰ Locus and Some of its AcrobaticsBiological Chemistry Hoppe-Seyler, 1990
- The Importance of CD5-Positive B Cells in Nonorgan-Specific Autoimmune DiseasesScandinavian Journal of Rheumatology, 1988
- CD5-positive B cells in rheumatoid arthritis and chronic lymphocytic leukemiaImmunology Today, 1987
- Idiotypic and genetic studies of human rheumatoid factorsArthritis & Rheumatism, 1987
- Expression of the T1 (CD5, p67) surface antigen in B‐CLL and B‐NHL and its correlation with other B‐cell differentiation markersHematological Oncology, 1986
- Screening Monoclonal Antibodies against Cell‐Surface Antigens High Frequency of Natural AntibodiesScandinavian Journal of Immunology, 1986
- Chronic B-cell leukemias: Relation between morphological and immunological featuresClinical Immunology and Immunopathology, 1985
- Normal equivalent cells of B cell malignancies: analysis with monoclonal antibodiesBritish Journal of Haematology, 1983