Angiogenesis in hepatocellular carcinoma: the retrospectives and perspectives
- 18 March 2004
- journal article
- review article
- Published by Springer Science and Business Media LLC in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 130 (6), 307-319
- https://doi.org/10.1007/s00432-003-0530-y
Abstract
Hepatocellular carcinoma (HCC) is a typical hypervascular tumor. Many angiogenic factors have been studied in HCC, and several anti-angiogenic therapies have been tested in animal models and patients. This paper summarizes the latest findings, especially regarding the clinical significance of endothelial cell markers and angiogenic factors in HCC, and experimental and clinical anti-angiogenesis therapies. Further developments in this area, such as endothelial cell-oriented research and better experimental and clinical designs in the evaluation of anti-angiogenic therapies are discussed.Keywords
This publication has 99 references indexed in Scilit:
- Microvessel Density, Vascular Endothelial Growth Factor and Its Receptors Flt-1 and Flk-1/KDR in Hepatocellular CarcinomaAmerican Journal of Clinical Pathology, 2001
- Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approachJournal of Hepatology, 2001
- Tumor hepatocytes and basement membrane–Producing cells specifically express two different forms of the endostatin precursor, collagen XVIII, in human liver cancersHepatology, 2001
- Increased proliferation activities of vascular endothelial cells and tumour cells in residual hepatocellular carcinoma following transcatheter arterial embolizationHistopathology, 2001
- Human Hepatitis B Virus X Protein Is a Possible Mediator of Hypoxia-Induced Angiogenesis in HepatocarcinogenesisBiochemical and Biophysical Research Communications, 2000
- Vascular endothelial growth factor tightly regulatesin vivo development of murine hepatocellular carcinoma cellsHepatology, 1998
- Thymidine phosphorylase (platelet-derived endothelial cell growth factor), microvessel density and clinical outcome in hepatocellular carcinomaJournal of Hepatology, 1998
- Inhibitory effect of the angiogenesis inhibitor TNP-470 on tumor growth and metastasis in nude mice bearing human hepatocellular carcinomaZeitschrift für Krebsforschung und Klinische Onkologie, 1997
- Plasma level of basic fibroblast growth factor increases with progression of chronic liver diseaseThe Esophagus, 1997
- An immunohistochemical study of the blood vessels within primary hepatocellular tumoursLiver International, 1992