Association Between Use of Specialty Dietary Supplements and C-Reactive Protein Concentrations
Open Access
- 8 November 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 176 (11), 1002-1013
- https://doi.org/10.1093/aje/kws186
Abstract
Laboratory evidence suggests that certain specialty dietary supplements have antiinflammatory properties, though evidence in humans remains limited. Data on a nationally representative sample of 9,947 adults from the 1999–2004 cycles of the National Health and Nutrition Examination Survey were used to assess the associations between specialty supplement use and inflammation, as measured by serum high-sensitivity C-reactive protein (hs-CRP) concentration. Using survey-weighted multivariate linear regression, significant reductions in hs-CRP concentrations were associated with regular use of glucosamine (17%, 95% confidence interval (CI): 7, 26), chondroitin (22%, 95% CI: 8, 33), and fish oil (16%, 95% CI: 0.3, 29). No associations were observed between hs-CRP concentration and regular use of supplements containing methylsulfonylmethane, garlic, ginkgo biloba, saw palmetto, or pycnogenol. These results suggest that glucosamine and chondroitin supplements are associated with reduced inflammation in humans and provide further evidence to support an inverse association between use of fish oil supplements and inflammation. It is important to further investigate the potential antiinflammatory role of these supplements, as there is a need to identify safe and effective ways to reduce inflammation and the burden of inflammation-related diseases such as cancer and cardiovascular disease.Keywords
This publication has 90 references indexed in Scilit:
- Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohortCancer Causes & Control, 2011
- Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trialsThe Lancet, 2011
- Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trialsThe Lancet, 2010
- Aspirin Adherence, Aspirin Dosage, and C-Reactive Protein in the First 3 Months After Acute Coronary SyndromeThe American Journal of Cardiology, 2010
- Changes in C-reactive protein from low-fat diet and/or physical activity in men and women with and without metabolic syndromeMetabolism, 2010
- Dietary docosahexaenoic and eicosapentaenoic acid: Emerging mediators of inflammationProstaglandins, Leukotrienes & Essential Fatty Acids, 2009
- Omega‐3 Dietary Supplements and the Risk of Cardiovascular Events: A Systematic ReviewClinical Cardiology, 2009
- Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statementThe Lancet Oncology, 2009
- Use of Prescription and Over-the-counter Medications and Dietary Supplements Among Older Adults in the United StatesPublished by American Medical Association (AMA) ,2008
- Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritisOsteoarthritis and Cartilage, 2007