Simulation of cellular irradiation with the CENBG microbeam line using GEANT4
- 16 August 2004
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Nuclear Science
- Vol. 51 (4), 1395-1401
- https://doi.org/10.1109/tns.2004.832224
Abstract
Light-ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high linear energy transfer ionizing radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of the CENBG 3.5 MV Van de Graaff accelerator. This setup delivers in air single protons and alpha particles of a few MeV onto cultured cells, with a spatial resolution of a few micrometers, allowing subcellular targeting. In this paper, we present results from the use of the GEANT4 toolkit to simulate cellular irradiation with the CENBG microbeam line, from the entrance to the microprobe up to the cellular medium. We show that a 3 MeV incident alpha particle may deliver a dose of 0.33 Gy to a typical cell nucleus.Keywords
This publication has 3 references indexed in Scilit:
- Geant4—a simulation toolkitNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2003
- Simulation of ion propagation in the microbeam line of CENBG using GEANT4Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2003
- Development of a single ion irradiation system at CENBG for applications in radiation biologyNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2001