Perspectives on NMR in drug discovery: a technique comes of age
- 1 September 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Drug Discovery
- Vol. 7 (9), 738-745
- https://doi.org/10.1038/nrd2606
Abstract
In the past decade, the ability of nuclear magnetic resonance (NMR) spectroscopy to provide information on intermolecular interactions that is valuable in drug discovery has been increasingly appreciated. Pellecchia and colleagues provide their collective evaluation of the major applications of NMR in drug discovery, focusing on hit and lead generation, and critically analyse its current and potential utility. In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.Keywords
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