Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent
- 11 October 2001
- journal article
- research article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 345 (15), 1098-1104
- https://doi.org/10.1056/nejmoa011110
Abstract
Infliximab is a humanized antibody against tumor necrosis factor α (TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis. Approximately 147,000 patients throughout the world have received infliximab. Excess TNF-α in association with tuberculosis may cause weight loss and night sweats, yet in animal models it has a protective role in the host response to tuberculosis. There is no direct evidence of a protective role of TNF-α in patients with tuberculosis.Keywords
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