Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem
Top Cited Papers
Open Access
- 16 October 2014
- journal article
- review article
- Published by SAGE Publications in Therapeutic Advances in Drug Safety
- Vol. 5 (6), 229-241
- https://doi.org/10.1177/2042098614554919
Abstract
Antimicrobial resistance is a global public health challenge, which has accelerated by the overuse of antibiotics worldwide. Increased antimicrobial resistance is the cause of severe infections, complications, longer hospital stays and increased mortality. Overprescribing of antibiotics is associated with an increased risk of adverse effects, more frequent re-attendance and increased medicalization of self-limiting conditions. Antibiotic overprescribing is a particular problem in primary care, where viruses cause most infections. About 90% of all antibiotic prescriptions are issued by general practitioners, and respiratory tract infections are the leading reason for prescribing. Multifaceted interventions to reduce overuse of antibiotics have been found to be effective and better than single initiatives. Interventions should encompass the enforcement of the policy of prohibiting the over-the-counter sale of antibiotics, the use of antimicrobial stewardship programmes, the active participation of clinicians in audits, the utilization of valid rapid point-of-care tests, the promotion of delayed antibiotic prescribing strategies, the enhancement of communication skills with patients with the aid of information brochures and the performance of more pragmatic studies in primary care with outcomes that are of clinicians’ interest, such as complications and clinical outcomes.Keywords
This publication has 86 references indexed in Scilit:
- Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trialThe Lancet, 2013
- Prescriber and Patient Responsibilities in Treatment of Acute Respiratory Tract Infections — Essential for Conservation of AntibioticsAntibiotics, 2013
- Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trialThe Lancet Infectious Diseases, 2013
- A Cluster Randomized Trial of Decision Support Strategies for Reducing Antibiotic Use in Acute BronchitisJAMA Internal Medicine, 2013
- Antibiotics for acute otitis media in childrenPublished by Wiley ,2013
- Non-prescription antimicrobial use worldwide: a systematic reviewThe Lancet Infectious Diseases, 2011
- Multiresistant Gram-negative infections: a global perspectiveCurrent Opinion in Infectious Diseases, 2010
- Systematic Review and Meta-Analysis of the Efficacy of Appropriate Empiric Antibiotic Therapy for SepsisAntimicrobial Agents and Chemotherapy, 2010
- Effect of Procalcitonin-Guided Treatment in Patients with Infections: a Systematic Review and Meta-AnalysisInfection, 2009
- Effect of using an interactive booklet about childhood respiratory tract infections in primary care consultations on reconsulting and antibiotic prescribing: a cluster randomised controlled trialBMJ, 2009