Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C–H Bond Amination
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- 3 May 2013
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 340 (6132), 591-595
- https://doi.org/10.1126/science.1233701
Abstract
Closing the Cycle: Cyclic hydrocarbons that incorporate nitrogen in the ring are among the most heavily investigated compounds in medicinal chemistry. Hennessy and Betley (p. 591 ) demonstrate an iron catalyst that forms a range of such cyclic compounds by inducing linear alkyl azides to curl back on themselves, inserting the nitrogen at one end into a carbon-hydrogen bond further down the chain. The reaction furthers a trend of C-H bond activation chemistry that forms elaborate products from relatively simple precursors, without the need to install activating groups at unreactive sites.Keywords
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