The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus
Open Access
- 3 February 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetology & Metabolic Syndrome
- Vol. 4 (1), 3-7
- https://doi.org/10.1186/1758-5996-4-3
Abstract
Hyperuricemia is associated with obesity. The visceral adiposity and subcutaneous adiposity may be associated with the differential metabolic risk, and the distribution of abdominal adipose tissue was significantly altered in people with type 2 diabetes mellitus (DM) compared to healthy people. Our study was performed to determine to the association between the regional abdominal adipose tissue distribution and serum uric acid levels in people with type 2 DM. A total of 699 people with type 2 DM and who had undergone abdominal computed tomography assessment of the visceral fat area and subcutaneous fat area were included. The serum uric acid levels were measured by the uricase method. Hyperuricemia was defined by cut-off value of > 7 mg/dl for men and > 6 mg/dl for women. The visceral fat area was positively associated with the serum uric acid levels after adjustment for age, sex, systolic blood pressure, diastolic blood pressure, serum creatinine, hemoglobin, serum albumin, serum high-density lipoprotein, serum triglyceride and hemoglobin A1c (β-coefficient = 0.117, p < 0.001). The logistic regression analysis showed that the visceral fat area was the significant independent predictor of hyperuricemia (OR 2.33, 95% CI, 1.21-4.50, p = 0.012). But there was no significant association between the subcutaneous fat area and the serum uric acid levels (β-coefficient = 0.061, p = 0.255). our data shows that the visceral fat area was positively associated with the serum uric acid levels, but the subcutaneous fat area was not in people with type 2 DM.Keywords
This publication has 35 references indexed in Scilit:
- Joint Association of Hyperuricemia and Reduced GFR on Cardiovascular Morbidity: A Historical Cohort Study Based on Laboratory and Claims Data From a National Insurance ProviderAmerican Journal of Kidney Diseases, 2011
- Hyperuricaemia and the metabolic syndrome in type 2 DMDiabetology & Metabolic Syndrome, 2010
- Adipose tissue distribution is different in type 2 diabetesThe American Journal of Clinical Nutrition, 2009
- Menopause, postmenopausal hormone use and serum uric acid levels in US women – The Third National Health and Nutrition Examination SurveyArthritis Research & Therapy, 2008
- Uric acid and the development of metabolic syndrome in women and menMetabolism, 2008
- Predictors of diabetic end‐stage renal disease in JapanNephrology, 2005
- Visceral Fat as a Determinant of Fibrinolysis and HemostasisSeminars in Vascular Medicine, 2005
- Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic SyndromeEndocrine Reviews, 2000
- Serum Uric Acid Is a Strong Predictor of Stroke in Patients With Non–Insulin-Dependent Diabetes MellitusStroke, 1998
- Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytesBiochemical and Biophysical Research Communications, 1987