Nutrition and brain development in early life
Top Cited Papers
Open Access
- 28 March 2014
- journal article
- review article
- Published by Oxford University Press (OUP) in Nutrition Reviews
- Vol. 72 (4), 267-284
- https://doi.org/10.1111/nure.12102
Abstract
Presented here is an overview of the pathway from early nutrient deficiency to long-term brain function, cognition, and productivity, focusing on research from low- and middle-income countries. Animal models have demonstrated the importance of adequate nutrition for the neurodevelopmental processes that occur rapidly during pregnancy and infancy, such as neuron proliferation and myelination. However, several factors influence whether nutrient deficiencies during this period cause permanent cognitive deficits in human populations, including the child's interaction with the environment, the timing and degree of nutrient deficiency, and the possibility of recovery. These factors should be taken into account in the design and interpretation of future research. Certain types of nutritional deficiency clearly impair brain development, including severe acute malnutrition, chronic undernutrition, iron deficiency, and iodine deficiency. While strategies such as salt iodization and micronutrient powders have been shown to improve these conditions, direct evidence of their impact on brain development is scarce. Other strategies also require further research, including supplementation with iron and other micronutrients, essential fatty acids, and fortified food supplements during pregnancy and infancy.Keywords
This publication has 136 references indexed in Scilit:
- Breast milk and cognitive development—the role of confounders: a systematic reviewBMJ Open, 2013
- Iodine and Mental Development of Children 5 Years Old and Under: A Systematic Review and Meta-AnalysisNutrients, 2013
- Iron-Fortified vs Low-Iron Infant FormulaArchives of Pediatrics & Adolescent Medicine, 2012
- Acquiring “the Knowledge” of London's Layout Drives Structural Brain ChangesCurrent Biology, 2011
- What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohortsInternational Journal of Epidemiology, 2011
- Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availabilityProceedings of the National Academy of Sciences of the United States of America, 2011
- Low birthweight and subsequent emotional and behavioural outcomes in 12-year-old children in Soweto, South Africa: findings from Birth to TwentyInternational Journal of Epidemiology, 2009
- Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female ratsEuropean Journal of Neuroscience, 2007
- Double Burden of Iron Deficiency in Infancy and Low Socioeconomic StatusArchives of Pediatrics & Adolescent Medicine, 2006
- Effect of breast feeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysisBMJ, 2006