Biopsy-based estimation of total nephron number in Japanese living kidney donors
- 12 January 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Clinical and Experimental Nephrology
- Vol. 23 (5), 629-637
- https://doi.org/10.1007/s10157-018-01686-2
Abstract
Increasing evidence suggests that individuals with low nephron number have an increased lifetime risk of renal insufficiency, thereby emphasizing the importance of evaluating total nephron number in each individual. In recent years, new methods have been described for estimating human total nephron number using a combination of image analysis and renal biopsy, though the reproducibility and accuracy of these methods remain uncertain. This study estimated total nephron number in healthy Japanese subjects using such a method.Keywords
Funding Information
- Kidney Foundation, Japan (JP25461236)
- Japan Society for the Promotion of Science (JP16K0936)
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