Dietary Exposure Estimation of Benzo[a]pyrene and Cancer Risk Assessment
- 5 July 2007
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Toxicology and Environmental Health, Part A
- Vol. 70 (15-16), 1391-1394
- https://doi.org/10.1080/15287390701434182
Abstract
Dietary benzo[a]pyrene (BaP) levels were analyzed by high-performance liquid chromatography with fluorescence detection (HPLC-FLD) in various foods (e.g., snack, potato chip, bread, vegetable oil, meat, cereal, etc.) to estimate dietary intake levels of BaP for the assessment of BaP related-cancer risk in Koreans. Higher levels of BaP were detected in fried chicken (5.25–5.55 BaP μg/kg) and smoked dried beef (5.47 μg/kg) compared to relatively lower levels measured in sesame oil (0.36 μg/kg) and peanut (0.44 μg/kg). The BaP levels in nonmeat items were generally low in detection, but certain potato chip products showed levels up to 4.06 BaP μg/kg. In terms of chronic daily intake of BaP, fried chicken was shown to be the highest (70.09 ng/person/d) and perilla oil was the lowest (0.05 ng/person/d). The total daily intake of BaP due to the consumption of various food items investigated was estimated to be 124.55 ng/person/d, based on daily food consumption and the contaminant level of BaP. The dietary BaP-related cancer risk using carcinogenic potency factor of BaP as 7.3E + 0 (mg/kg/d)−1 was assessed to be 1.52 × 10−5. These data suggest that cancer risk due to dietary exposure to BaP is of concern in Koreans and needs to be reduced either by regulatory efforts or by modifying food manufacturing procedures.This publication has 14 references indexed in Scilit:
- Age-related Changes in Oxidative DNA Damage and Benzo(a)pyrene Diolepoxide-I (BPDE-I)-DNA Adduct Levels in Human StomachJournal of Toxicology and Environmental Health, Part A, 2005
- Crop-specific human exposure assessment for polycyclic aromatic hydrocarbons in Czech soilsScience of The Total Environment, 2005
- Determination of benzo[a]pyrene in charcoal grilled meat samples by HPLC with fluorescence detectionInternational Journal of Food Sciences and Nutrition, 2005
- Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control studyCarcinogenesis: Integrative Cancer Research, 2004
- Levels of Benzo[a]pyrene (BaP) in “Mozzarella di Bufala Campana” Cheese Smoked According to Different ProceduresJournal of Agricultural and Food Chemistry, 2004
- Determination of High Molecular Mass Polycyclic Aromatic Hydrocarbons in a Typical Italian Smoked Cheese by HPLC-FLJournal of Agricultural and Food Chemistry, 2003
- EFFECTS OF pH AND TEMPERATURE ON BENZO[a]PYRENE-DNA, -PROTEIN, AND -LIPID ADDUCTS IN PRIMARY RAT HEPATOCYTESJournal of Toxicology and Environmental Health, Part A, 2002
- Determination of benzo[a]pyrene in some Spanish commercial smoked products by HPLC-FLFood Additives & Contaminants, 1999
- Polycyclic aromatic hydrocarbon-DNA adducts in lung tissue from lung cancer patientsCarcinogenesis: Integrative Cancer Research, 1990
- Quantitation of protein adducts as a marker of genotoxic exposure: immunologic detection of benzo(a)pyrene — globin adducts in miceCarcinogenesis: Integrative Cancer Research, 1988