Size, weight and position: ion mobility spectrometry and imaging MS combined
Open Access
- 13 January 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Analytical and Bioanalytical Chemistry
- Vol. 399 (8), 2623-2634
- https://doi.org/10.1007/s00216-010-4644-1
Abstract
Size, weight and position are three of the most important parameters that describe a molecule in a biological system. Ion mobility spectrometry is capable of separating molecules on the basis of their size or shape, whereas imaging mass spectrometry is an effective tool to measure the molecular weight and spatial distribution of molecules. Recent developments in both fields enabled the combination of the two technologies. As a result, ion-mobility-based imaging mass spectrometry is gaining more and more popularity as a (bio-)analytical tool enabling the determination of the size, weight and position of several molecules simultaneously on biological surfaces. This paper reviews the evolution of ion-mobility-based imaging mass spectrometry and provides examples of its application in analytical studies of biological surfaces.Keywords
This publication has 104 references indexed in Scilit:
- Improving FAIMS sensitivity using a planar geometry with slit interfacesJournal of the American Society for Mass Spectrometry, 2009
- Overtone mobility spectrometry: Part 2. Theoretical considerations of resolving powerJournal of the American Society for Mass Spectrometry, 2009
- Overtone mobility spectrometry: Part 1. Experimental observationsJournal of the American Society for Mass Spectrometry, 2009
- Characterizing ion mobility-mass spectrometry conformation space for the analysis of complex biological samplesAnalytical and Bioanalytical Chemistry, 2009
- High-Resolution Ion Cyclotron Mobility SpectrometryAnalytical Chemistry, 2009
- Fundamentals of Traveling Wave Ion Mobility SpectrometryAnalytical Chemistry, 2008
- Resolving and assigning N-linked glycan structural isomers from ovalbumin by IMS-MSJournal of the American Society for Mass Spectrometry, 2008
- A study of phospholipids by ion mobility TOFMSJournal of the American Society for Mass Spectrometry, 2008
- Stability and Shape of Hepatitis B Virus Capsids In VacuoAngewandte Chemie-International Edition, 2008
- MALDI‐ion mobility‐TOFMS imaging of lipids in rat brain tissueJournal of Mass Spectrometry, 2007