Establishment and development of intestinal microbiota in preterm neonates
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Open Access
- 15 December 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in FEMS Microbiology Ecology
- Vol. 79 (3), 763-772
- https://doi.org/10.1111/j.1574-6941.2011.01261.x
Abstract
Microbial colonization of the infant gut is essential for the development of the intestine and the immune system. The profile of intestinal microbiota in the full-term, vaginally delivered, breast-fed infant is considered as ideally healthy. However, in preterm infants this process is challenging, mainly because of organ immaturity, antibiotics use, and hospital stay. To assist in a proper microbiota development in these infants, a detailed knowledge of the colonization process, and the differences from that of full-term breast-fed infants, is needed. We assessed the establishment of the gut microbiota and its metabolic activity in preterm neonates (n = 21) during the first 3 months of life and compared it with that of vaginally delivered, exclusively breast-fed full-term infants (n = 20) using qualitative and quantitative culture-independent methods. Differences in the gut microbiota composition between both groups were observed. Preterm infants showed higher levels of facultative anaerobic microorganisms and reduced levels of strict anaerobes such as Bifidobacterium, Bacteroides, and Atopobium. Short-chain fatty acids concentrations were lower in preterm infants during the first days of life. Alterations occur in the process of microbiota establishment in preterm infants, indicating the need for intervention strategies to counteract them.Keywords
This publication has 43 references indexed in Scilit:
- Dynamics and Clinical Evolution of Bacterial Gut Microflora in Extremely Premature PatientsThe Journal of Pediatrics, 2011
- Clostridium difficile Colonization in Early Infancy Is Accompanied by Changes in Intestinal Microbiota CompositionJournal of Clinical Microbiology, 2011
- Strain-resolved community genomic analysis of gut microbial colonization in a premature infantProceedings of the National Academy of Sciences of the United States of America, 2010
- Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharidesTrends in Microbiology, 2010
- Intestinal Microbial Ecology in Premature Infants Assessed with Non–Culture-Based TechniquesThe Journal of Pediatrics, 2010
- Optimized PCR-Temporal Temperature Gel Electrophoresis compared to cultivation to assess diversity of gut microbiota in neonatesJournal of Microbiological Methods, 2009
- The long-term health effects of neonatal microbial floraCurrent Opinion in Allergy and Clinical Immunology, 2009
- 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitisThe ISME Journal, 2009
- Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the ElderlyApplied and Environmental Microbiology, 2007
- Sensitive Quantitative Detection of Commensal Bacteria by rRNA-Targeted Reverse Transcription-PCRApplied and Environmental Microbiology, 2007