Transcription activation by the adenovirus E1a protein
- 1 March 1989
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 338 (6210), 39-44
- https://doi.org/10.1038/338039a0
Abstract
The adenovirus E1a protein stimulates transcription of a wide variety of viral and cellular genes. It is shown here that E1a has the two functions characteristic of a typical cellular activator: one direct E1a to the promoter, perhaps by interacting with a DNA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.Keywords
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