Development of mucoadhesive poly(lactide-co-glycolide) nanoparticles for ocular application
- 29 December 2009
- journal article
- Published by Informa UK Limited in Pharmaceutical Development and Technology
- Vol. 16 (1), 29-35
- https://doi.org/10.3109/10837450903479954
Abstract
Pilocarpine loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by solvent evaporation method and coated with various mucoadhesive polymers, in particular chitosan, sodium alginate and poloxamers. The size of chitosan-coated nanoparticles was larger than the size of all the other particles obtained. Their surface charge was changed from negative (−22.8 mV) to positive (+61.0 mV). The interaction between mucin and chitosan-coated nanoparticles took place up to six hours according to turbidimetric study. The positive charge of chitosan-coated nanoparticles decreased significantly six hours after incubation in mucin dispersion, which was attributed to their electrostatic interaction. The coating with chitosan could be considered useful approach aiming to prolong nanoparticle residence time after local ocular application.Keywords
This publication has 20 references indexed in Scilit:
- Adhesion of PLGA or Eudragit®/PLGA nanoparticles to Staphylococcus and PseudomonasInternational Journal of Pharmaceutics, 2008
- Evaluation of bioadhesive potential and intestinal transport of pegylated poly(anhydride) nanoparticlesInternational Journal of Pharmaceutics, 2007
- Design of poly-ε-caprolactone nanospheres coated with bioadhesive hyaluronic acid for ocular deliveryJournal of Controlled Release, 2002
- Efficacy of Ganciclovir-loaded Nanoparticles in Human Cytomegalovirus (HCMV)-infected CellsJournal of Drug Targeting, 2002
- Evaluation of cationic polymer-coated nanocapsules as ocular drug carriersInternational Journal of Pharmaceutics, 1997
- Microspheres and nanoparticles used in ocular delivery systemsAdvanced Drug Delivery Reviews, 1995
- Precorneal Clearance of Mucoadhesive Microspheres from the Rabbit EyeJournal of Pharmacy and Pharmacology, 1995
- Evaluation of pilocarpine-loaded albumin particles as controlled drug delivery systems for the eye. II. Co-administration with bioadhesive and viscous polymersJournal of Controlled Release, 1995
- Factors Influencing Gel-strengthening at the Mucoadhesive-mucus InterfaceJournal of Pharmacy and Pharmacology, 1994
- Design and evaluation of controlled release systems for the eyeJournal of Controlled Release, 1987