The Potential for CYP2D6 Inhibition Screening Using a Novel Scintillation Proximity Assay-Based Approach
Open Access
- 1 August 2001
- journal article
- research article
- Published by Elsevier BV in SLAS Discovery
- Vol. 6 (4), 225-231
- https://doi.org/10.1177/108705710100600404
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Description of a 96-Well Plate Assay to Measure Cytochrome P4503A Inhibition in Human Liver Microsomes Using a Selective Fluorescent ProbeAnalytical Biochemistry, 1999
- Inhibitory monoclonal antibodies to human cytochrome P450 enzymes: a new avenue for drug discoveryTrends in Pharmacological Sciences, 1999
- Advances in in vitro drug metabolism screeningPharmaceutical Science & Technology Today, 1999
- Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potentialXenobiotica, 1999
- What lessons can be learnt from withdrawal of mibefradil from the market?The Lancet, 1998
- Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substratesRapid Communications in Mass Spectrometry, 1998
- Preclinical Drug Metabolism in the Age of High-Throughput Screening: An Industrial PerspectivePharmaceutical Research, 1997
- Role of Cytochrome P450 Enzymes in Drug-Drug InteractionsAdvances in Pharmacology, 1997
- Measurement of Liver Microsomal Cytochrome P450 (CYP2D6) Activity Using [O-methyl-14C] DextromethorphanAnalytical Biochemistry, 1994
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973