Anti-inflammatory activity of chondroitin sulphate: new functions from an old natural macromolecule
- 1 November 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Inflammopharmacology
- Vol. 19 (6), 299-306
- https://doi.org/10.1007/s10787-011-0098-0
Abstract
Chondroitin sulphate (CS) is recommended by the European League Against Rheumatism as a symptomatic slow-acting drug for the treatment of osteoarthritis on the basis of numerous clinical trials and meta-analyses. Furthermore, recent clinical trials have also demonstrated the possible structure-modifying effects of CS. This review focuses on recent experimental results and data available in the scientific literature regarding the anti-inflammatory properties of CS with a view to understanding the molecular basis responsible for its activity. Several animal studies have demonstrated that orally administered CS significantly inhibited hind paw oedema, synovitis and destruction of the articular cartilage in a dose-dependent manner. Furthermore, CS proved to have a beneficial effect in slowing down the development of adjuvant arthritis and in reducing disease markers, findings which support its beneficial activity in humans as a chondroprotective drug. Finally, several in vitro studies have focused on the hypothesis that CS may reduce inflammatory processes by acting on the nuclear translocation of NF-κB, which is closely associated with the blood biomarkers of inflammation, primarily IL-1, IL-6 and C-reactive protein.Keywords
This publication has 35 references indexed in Scilit:
- Old and new generation lipid mediators in acute inflammation and resolutionProgress in Lipid Research, 2011
- Dermatan sulfate: Recent structural and activity dataCarbohydrate Polymers, 2010
- Quality of different chondroitin sulfate preparations in relation to their therapeutic activityJournal of Pharmacy and Pharmacology, 2009
- Quality of different chondroitin sulfate preparations in relation to their therapeutic activityJournal of Pharmacy and Pharmacology, 2009
- New regulators of NF-κB in inflammationNature Reviews Immunology, 2008
- Effect of chondroitin sulphate in a rabbit model of atherosclerosis aggravated by chronic arthritisBritish Journal of Pharmacology, 2008
- Chondroitin Sulfate Inhibits the Nuclear Translocation of Nuclear Factor‐κB in Interleukin‐1β‐Stimulated ChondrocytesBasic & Clinical Pharmacology & Toxicology, 2007
- EULAR evidence based recommendations for the management of hand osteoarthritis: Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)Annals Of The Rheumatic Diseases, 2007
- NF-κB at the crossroads of life and deathNature Immunology, 2002
- Animal Models of Arthritis: Relevance to Human DiseaseToxicologic Pathology, 1999