Abstract
In this paper, we investigate the noncommutative KKLMMT D3/anti-D3 brane inflation scenario in detail. Incorporation of the brane inflation scenario and the noncommutative inflation scenario can nicely explain the large negative running of the spectral index as indicated by WMAP three-year data and can significantly release the fine-tuning for the parameter $eta$. Using the WMAP three year results (blue-tilted spectral index with large negative running), we explore the parameter space and give the constraints and predictions for the inflationary parameters and cosmological observables in this scenario. We show that this scenario predicts a quite large tensor/scalar ratio and what is more, a too large cosmic string tension (assuming that the string coupling $g_s$ is in its likely range from 0.1 to 1) to be compatible with the present observational bound. A more detailed analysis reveals that this model has some inconsistencies according to the fit to WMAP three year results.