SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function
- 31 August 2010
- journal article
- review article
- Published by Wiley in Journal Of Physiology-London
- Vol. 588 (17), 3169-3178
- https://doi.org/10.1113/jphysiol.2010.191585
Abstract
Many types of ion channel localize to cholesterol and sphingolipid-enriched regions of the plasma membrane known as lipid microdomains or 'rafts'. The precise physiological role of these unique lipid microenvironments remains elusive due largely to difficulties associated with studying these potentially extremely small and dynamic domains. Nevertheless, increasing evidence suggests that membrane rafts regulate channel function in a number of different ways. Raft-enriched lipids such as cholesterol and sphingolipids exert effects on channel activity either through direct protein-lipid interactions or by influencing the physical properties of the bilayer. Rafts also appear to selectively recruit interacting signalling molecules to generate subcellular compartments that may be important for efficient and selective signal transduction. Direct interaction with raft-associated scaffold proteins such as caveolin can also influence channel function by altering gating kinetics or by affecting trafficking and surface expression. Selective association of ion channels with specific lipid microenvironments within the membrane is thus likely to be an important and fundamental regulatory aspect of channel physiology. This brief review highlights some of the existing evidence for raft modulation of channel function.Keywords
This publication has 70 references indexed in Scilit:
- Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1Proceedings of the National Academy of Sciences of the United States of America, 2009
- A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling techniqueProceedings of the National Academy of Sciences of the United States of America, 2009
- Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterolProceedings of the National Academy of Sciences of the United States of America, 2009
- The Activity of the Epithelial Sodium Channels Is Regulated by Caveolin-1 via a Nedd4-2-dependent MechanismOnline Journal of Public Health Informatics, 2009
- Caveolae, ion channels and cardiac arrhythmiasProgress in Biophysics and Molecular Biology, 2008
- The multiple faces of caveolaeNature Reviews Molecular Cell Biology, 2007
- Biochemical characterization of detergent-resistant membranes: a systematic approachBiochemical Journal, 2006
- Localization of cardiac L-type Ca 2+ channels to a caveolar macromolecular signaling complex is required for β 2 -adrenergic regulationProceedings of the National Academy of Sciences of the United States of America, 2006
- Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factorsProceedings of the National Academy of Sciences of the United States of America, 2003
- A detergent-free method for purifying caveolae membrane from tissue culture cells.Proceedings of the National Academy of Sciences of the United States of America, 1995