The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification
Top Cited Papers
- 1 January 2008
- journal article
- review article
- Published by Informa UK Limited in Drug Metabolism Reviews
- Vol. 40 (4), 553-624
- https://doi.org/10.1080/03602530802431439
Abstract
The aldo-keto reductase (AKR) superfamily comprises enzymes that catalyze redox transformations involved in biosynthesis, intermediary metabolism, and detoxification. Substrates of AKRs include glucose, steroids, glycosylation end-products, lipid peroxidation products, and environmental pollutants. These proteins adopt a (β /α )8 barrel structural motif interrupted by a number of extraneous loops and helixes that vary between proteins and bring structural identity to individual families. The human AKR family differs from the rodent families. Due to their broad substrate specificity, AKRs play an important role in the phase II detoxification of a large number of pharmaceuticals, drugs, and xenobiotics.Keywords
This publication has 319 references indexed in Scilit:
- Merging the Binding Sites of Aldose and Aldehyde Reductase for Detection of Inhibitor Selectivity-determining FeaturesJournal of Molecular Biology, 2008
- An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignanciesBiochemical Pharmacology, 2008
- Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphismsArchives of Biochemistry and Biophysics, 2007
- NADPH binding to β-subunit regulates inactivation of voltage-gated K+ channelsBiochemical and Biophysical Research Communications, 2007
- Mouse 17α-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate BindingJournal of Molecular Biology, 2007
- Enzymology of a carbonyl reduction clearance pathway for the HIV integrase inhibitor, S-1360: role of human liver cytosolic aldo-keto reductasesChemico-Biological Interactions, 2004
- Cardiovascular Risks and Benefits of Perioperative Nonsteroidal Anti-Inflammatory Drug TreatmentDrugs, 1992
- Regeneration and Repair of Myelinated Fibers in Sural-Nerve Biopsy Specimens from Patients with Diabetic Neuropathy Treated with SorbinilNew England Journal of Medicine, 1988
- Nerve Glucose, Fructose, Sorbitol,myo-Inositol, and Fiber Degeneration and Regeneration in Diabetic NeuropathyNew England Journal of Medicine, 1988
- NaltrexoneDrugs, 1988