Eighty-one patients with squamous cell carcinoma of the glossopalatine sulcus received definitive megavoltage irradiation at M.D. Anderson Hospital and Tumor Institute. Such tumors have a specific natural history and spread pattern. Almost all T2 and T3 lesions are controlled with 7,000 rads/7 wk.-7,500 rads/7½ wk. The time-dose data for control of these lesions by radiotherapy indicate the importance of precise treatment. Complications are found to be dose related.