Guidance of Vascular Development
Open Access
- 27 February 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 104 (4), 428-441
- https://doi.org/10.1161/circresaha.108.188144
Abstract
The vascular system of vertebrates consists of an organized, branched network of arteries, veins, and capillaries that penetrates all the tissues of the body. One of the most striking features of the vascular system is that its branching pattern is highly stereotyped, with major and secondary branches forming at specific sites and developing highly conserved organ-specific vascular patterns. The factors controlling vascular patterning are not yet completely understood. Recent studies have highlighted the anatomic and structural similarities between blood vessels and nerves. The 2 networks are often aligned, with nerve fibers and blood vessels following parallel routes. Furthermore, both systems require precise control over their guidance and growth. Several molecules with attractive and repulsive properties have been found to modulate the proper guidance of both nerves and blood vessels. These include the Semaphorins, the Slits, and the Netrins and their receptors. In this review, we describe the molecular mechanisms by which blood vessels and axons achieve proper path finding and the molecular cues that are involved in their guidance.Keywords
This publication has 125 references indexed in Scilit:
- DSCAM Is a Netrin Receptor that Collaborates with DCC in Mediating Turning Responses to Netrin-1Cell, 2008
- Endothelins are vascular-derived axonal guidance cues for developing sympathetic neuronsNature, 2008
- Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeabilityNature Medicine, 2008
- Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF bindingThe EMBO Journal, 2007
- Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanismProceedings of the National Academy of Sciences, 2006
- Common mechanisms of nerve and blood vessel wiringNature, 2005
- Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural developmentJournal of Neurobiology, 2004
- The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factorsNature, 2001
- Deleted in Colorectal Cancer (DCC) Encodes a Netrin ReceptorCell, 1996
- The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6Cell, 1994