Persistent organochlorine pesticides in serum and risk of Parkinson disease
- 30 March 2010
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 74 (13), 1055-1061
- https://doi.org/10.1212/wnl.0b013e3181d76a93
Abstract
Background: Pesticides have been implicated as likely environmental risk factors for Parkinson disease (PD), but assessment of past exposure to pesticides can be difficult. No prior studies of pesticide exposure and PD used biomarkers of exposure collected before the onset of PD. Our investigation examined the association between prospective serum biomarkers of organochlorine pesticides and PD. Methods: We conducted a nested case-control study within the Finnish Mobile Clinic Health Examination Survey, with serum samples collected during 1968–1972, and analyzed in 2005–2007 for organochlorine pesticides. Incident PD cases were identified through the Social Insurance Institution's nationwide registry and were confirmed by review of medical records (n = 101). Controls (n = 349) were matched for age, sex, municipality, and vital status. Adjusted odds ratios (ORs) of PD were estimated using logistic regression. Results: Little association emerged with a summary score of the 5 organochlorine pesticides found at high levels, and only increasing dieldrin concentrations trended toward a higher risk of PD (OR per interquartile range [IQR] 1.28, 95% confidence interval [CI] 0.97–1.69, p = 0.08). Because of possible strong confounding by cigarette smoking among smokers, we ran additional analyses restricted to never smokers (n = 68 cases, 183 controls). In these analyses, increasing dieldrin concentrations were associated with increased odds of PD (OR per IQR 1.95, 95% CI 1.26–3.02, p = 0.003). None of the other organochlorine pesticides were associated with PD in these analyses. Conclusions: These results provide some support for an increased risk of Parkinson disease with exposure to dieldrin, but chance or exposure correlation with other less persistent pesticides could contribute to our findings.Keywords
This publication has 31 references indexed in Scilit:
- Professional exposure to pesticides and Parkinson diseaseAnnals of Neurology, 2009
- Dieldrin-Induced Neurotoxicity: Relevance to Parkinson's Disease PathogenesisNeuroToxicology, 2005
- Parkinson’s disease among Inuit in Greenland: organochlorines as risk factorsInternational Journal of Circumpolar Health, 2004
- Pesticides directly accelerate the rate of α‐synuclein fibril formation: a possible factor in Parkinson's diseaseFEBS Letters, 2001
- Measurement of PCBs, DDE, and hexachlorobenzene in cord blood from infants born in towns adjacent to a PCB-contaminated waste siteJournal of Exposure Science & Environmental Epidemiology, 2000
- ORGANOCHLORINE INSECTICIDES IN SUBSTANTIA NIGRA IN PARKINSON'S DISEASEJournal of Toxicology and Environmental Health, Part A, 2000
- Environmental risk factors in Parkinson's diseaseMovement Disorders, 1999
- Parkinson Disease in TwinsAn Etiologic StudyJAMA, 1999
- Diagnostic Criteria for Parkinson DiseaseArchives of Neurology, 1999
- Possible environmental, occupational, and other etiologic factors for Parkinson's diseaseNeurology, 1996