Germinal centres and the B-cell system. V
- 31 July 1981
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 219 (2), 281-289
- https://doi.org/10.1007/bf00210148
Abstract
Thoracic duct lymphocytes (TDL) were studied with respect to their capacity to give rise to germinal centres (GC) and to form primary antibody in an adoptive transfer system of the rat. Challenge with sheep erythrocytes (SRBC) 24h after lethal irradiation (900 rads) and syngeneic TDL reconstitution (108) lead to conspicuous GC activity already 7 days after transfer. In contrast, using syngeneic bone marrow (BM) in the adoptive transfer system, no GC formation was observed over the period studied (14 days after reconstitution). Reconstitution experiments using in vivo-separated T-TDL (1–5 % s-Ig+) and B-TDL (>90% s-Ig+) subpopulations, either separately or in combination, indicated that GC originate from B-TDL but require T-TDL for induction.Keywords
This publication has 8 references indexed in Scilit:
- Germinal centres and the B cell systemVirchows Archiv B Cell Pathology Including Molecular Pathology, 1980
- Germinal Centres and the B-Cell System: A Search for the Germinal Centre Precursor Cell in the RatAdvances in experimental medicine and biology, 1979
- B lymphocyte differentiation in lethally irradiated and reconstituted miceCell and tissue research, 1978
- The identification of sera distinguishing marrow-derived and thymus-derived lymphocytes in the rat thoracic duct.1974
- Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) miceCellular Immunology, 1974
- Germinal centres and the origin of the B-cell system. II. Germinal centres in the rabbit spleen and popliteal lymph nodes.1974
- Germinal centres and the origin of the B-cell system. I. Germinal centres in the rabbit appendix.1974
- Involvement of thymus cells in the formation of germinal centersCells Tissues Organs, 1974