Molecular Basis of Ethnic Differences in Drug Disposition and Response
Top Cited Papers
- 1 April 2001
- journal article
- review article
- Published by Annual Reviews in Annual Review of Pharmacology and Toxicology
- Vol. 41 (1), 815-850
- https://doi.org/10.1146/annurev.pharmtox.41.1.815
Abstract
Ethnicity is an important demographic variable contributing to interindividual variability in drug metabolism and response. In this rapidly expanding research area many genetic factors that account for the effects of ethnicity on pharmacokinetics, pharmacodynamics, and drug safety have been identified. This review focuses on recent developments that have improved understanding of the molecular mechanisms responsible for such interethnic differences. Genetic variations that may provide a molecular basis for ethnic differences in drug metabolizing enzymes (CYP 2C9, 2C19, 2D6, and 3A4), drug transporter (P-glycoprotein), drug receptors (adrenoceptors), and other functionally important proteins (eNOS and G proteins) are discussed. A better understanding of the molecular basis underlying ethnic differences in drug metabolism, transport, and response will contribute to improved individualization of drug therapy.Keywords
This publication has 94 references indexed in Scilit:
- Genetic variations of S-mephenytoin 4′-hydroxylase (CYP2C19) in the chinese populationLife Sciences, 2000
- Low frequency of defective alleles of cytochrome P450 enzymes 2C19 and 2D6 in the Turkish populationClinical Pharmacology & Therapeutics, 1999
- Characterization of a Unique Genetic Variant in the β1-adrenoceptor Gene and Evaluation of its Role in Idiopathic Dilated CardiomyopathyJournal of Molecular and Cellular Cardiology, 1999
- Interindividual Differences in Hepatic Expression of CYP3A4: Relationship to Genetic Polymorphism in the 5′-Upstream Regulatory RegionBiochemical and Biophysical Research Communications, 1999
- Validation of Methods for CYP2C9 Genotyping: Frequencies of Mutant Alleles in a Swedish PopulationBiochemical and Biophysical Research Communications, 1999
- Reduced β2-receptor mediated vasodilation in African AmericansLife Sciences, 1995
- Sequence of the 5′-Flanking Region of CYP3A5: Comparative Analysis with CYP3A4 and CYP3A7Biochemical and Biophysical Research Communications, 1994
- Gene Structure and Upstream Regulatory Regions of Human CYP2C9 and CYP2C18Biochemical and Biophysical Research Communications, 1993
- Interethnic variation of drug metabolismTrends in Pharmacological Sciences, 1991
- Intraindividual variability in the relative systemic availability of cyclosporin after oral dosingEuropean Journal of Clinical Pharmacology, 1988