Post-COVID-19 Fatigue: Potential Contributing Factors
Open Access
- 19 December 2020
- journal article
- perspective
- Published by MDPI AG in Brain Sciences
- Vol. 10 (12), 1012
- https://doi.org/10.3390/brainsci10121012
Abstract
Much of the spotlight for coronavirus disease 2019 (COVID-19) is on the acute symptoms and recovery. However, many recovered patients face persistent physical, cognitive, and psychological symptoms well past the acute phase. Of these symptoms, fatigue is one of the most persistent and debilitating. In this “perspective article,” we define fatigue as the decrease in physical and/or mental performance that results from changes in central, psychological, and/or peripheral factors due to the COVID-19 disease and propose a model to explain potential factors contributing to post-COVID-19 fatigue. According to our model, fatigue is dependent on conditional and physiological factors. Conditional dependency comprises the task, environment, and physical and mental capacity of individuals, while physiological factors include central, psychological, and peripheral aspects. This model provides a framework for clinicians and researchers. However, future research is needed to validate our proposed model and elucidate all mechanisms of fatigue due to COVID-19.Keywords
This publication has 54 references indexed in Scilit:
- Regulation of Satellite Cell Function in SarcopeniaFrontiers in Aging Neuroscience, 2014
- Neuroinvasive and Neurotropic Human Respiratory Coronaviruses: Potential Neurovirulent Agents in HumansPublished by Springer Science and Business Media LLC ,2014
- Unraveling the neurophysiology of muscle fatigueJournal of Electromyography and Kinesiology, 2011
- Central and Peripheral Fatigue: Exemplified by Multiple Sclerosis and Myasthenia GravisPM&R, 2010
- Mental Morbidities and Chronic Fatigue in Severe Acute Respiratory Syndrome SurvivorsArchives of Internal Medicine, 2009
- Functional Neuroimaging of FatiguePhysical Medicine and Rehabilitation Clinics of North America, 2009
- One-Year Outcomes and Health Care Utilization in Survivors of Severe Acute Respiratory SyndromeArchives of Internal Medicine, 2007
- Central FatigueSports Medicine, 2006
- Fatigue in multiple sclerosis and its relationship to depression and neurologic disabilityMultiple Sclerosis Journal, 2000
- Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigueNeurology, 1997