Increased expression of Rab coupling protein in squamous cell carcinoma of the head and neck and its clinical significance
Open Access
- 23 March 2012
- journal article
- Published by Spandidos Publications in Oncology Letters
- Vol. 3 (6), 1231-1236
- https://doi.org/10.3892/ol.2012.652
Abstract
The role of Rab coupling protein (RCP) has not been previously investigated in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to explore RCP protein expression and its clinicopathological significance in SCCHN. RCP protein expression in 95 SCCHN samples, 18 vocal nodule epithelia and 16 leukoplakia epithelia samples was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patient outcome. Our data indicated that vocal nodule epithelia, leukoplakia epithelia and SCCHN showed a gradual increase in the expression of RCP protein. RCP overexpression was significantly associated with T classification, clinical staging, lymph node metastasis and recurrence. Survival analysis revealed that a high RCP expression was significantly correlated with shorter overall survival and disease-free survival. In conclusion, RCP protein may contribute to the malignant progression of SCCHN, and serves as a novel prognostic marker in patients with SCCHN.Keywords
This publication has 12 references indexed in Scilit:
- β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cellsOncogene, 2011
- Co‐overexpression of p21 and Ki‐67 in head and neck squamous cell carcinoma relative to a significantly poor prognosisHead & Neck, 2011
- Role of Rab GTPases in Membrane Traffic and Cell PhysiologyPhysiological Reviews, 2011
- Elevated expression of HMGB1 in squamous-cell carcinoma of the head and neck and its clinical significanceEuropean Journal Of Cancer, 2010
- Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironmentsThe Journal of cell biology, 2008
- Cancer Statistics, 2008CA: A Cancer Journal for Clinicians, 2008
- Overexpression of podoplanin in oral cancer and its association with poor clinical outcomeCancer, 2006
- Clinical Proteomics and Biomarker DiscoveryAnnals of the New York Academy of Sciences, 2004
- The subapical compartment: a traffic center in membrane polarity developmentJournal of Cell Science, 2004
- Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer: A multivariate study of 492 casesCancer, 1992