Time Trends in Oligodendroglial and Astrocytic Tumor Incidence
- 6 February 2008
- journal article
- research article
- Published by S. Karger AG in Neuroepidemiology
- Vol. 30 (1), 34-44
- https://doi.org/10.1159/000115440
Abstract
Background: We hypothesized that the incidences of oligodendrogliomas, anaplastic oligodendrogliomas, and mixed gliomas have significantly increased from the early 1990s forward, while the incidences of anaplastic and grade II astrocytic tumors have significantly decreased. Methods: Data for the years 1973–2004 from the Surveillance, Epidemiology and End Results (SEER) public-use data and for 1985–2004 from six collaborating registries of the Central Brain Tumor Registry of the US (CBTRUS) were obtained. SEER*Stat was used to estimate age-adjusted incidence trends and annual percent change (APC) for selected histologies. Joinpoint regression was used to identify sharp changes in incidences occurring over time. Results: Using CBTRUS data, the incidences (per 100,000 person-years) of oligodendrogliomas (APC = 4.7), mixed gliomas (APC = 3.9) and anaplastic oligodendrogliomas (APC = 12.5) have all increased over time, while the incidences of astrocytoma not otherwise specified (APC = –8.1) and fibrillary astrocytoma (APC = –2.1) have decreased. Restricting the analyses to later years (1992–2004) using SEER data shows the incidence of oligodendrogliomas leveling off (APC = 0.5), while joinpoint analyses demonstrate a decreasing trend after 1998. Conclusions: This study has demonstrated that increases in oligodendroglial tumor incidence correspond to decreases in astrocytic tumor incidence over the same time period. Minimizing misclassification of glial tumors will be essential for accurately assessing incidence, survival, and mortality rates, as well as for identifying homogeneous subgroups for epidemiologic and treatment studies.Keywords
This publication has 23 references indexed in Scilit:
- A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q and Predicts a Better Prognosis of Patients with OligodendrogliomaCancer Research, 2006
- Consistency of Primary Brain Tumor Diagnoses and Codes in Cancer Surveillance SystemsNeuroepidemiology, 2004
- Recent developments in the molecular characterization and treatment of oligodendroglial tumorsNeuro-Oncology, 2003
- Chromosomal anomalies in oligodendroglial tumors are correlated with clinical featuresCancer, 2003
- What is an Oligodendroglioma?Brain Pathology, 2002
- Losses of Chromosomal Arms 1p and 19q in the Diagnosis of Oligodendroglioma. A Study of Paraffin-Embedded SectionsLaboratory Investigation, 2001
- Subtyping of oligo-astrocytic tumours by comparative genomic hybridizationThe Journal of Pathology, 2001
- Molecular Genetic Aspects of Oligodendrogliomas Including Analysis by Comparative Genomic HybridizationThe American Journal of Pathology, 1999
- Allelic loss at 1p and 19q frequently occurs in association and may represent early oncogenic events in oligodendroglial tumorsInternational Journal of Cancer, 1995
- The New WHO Classification of Brain TumoursBrain Pathology, 1993