Perirhinal and Parahippocampal Cortices Differentially Contribute to Later Recollection of Object- and Scene-Related Event Details
- 15 June 2011
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 31 (24), 8739-8747
- https://doi.org/10.1523/jneurosci.4978-10.2011
Abstract
How the different elements of our experiences are encoded into episodic memories has remained one of the major questions in memory research. Although the pivotal role of the medial temporal lobe as a whole for memory formation is well established, much controversy surrounds the precise contributions of the subregions in the medial temporal lobe cortex (MTLC), most notably the perirhinal cortex (PrC) and the parahippocampal cortex (PhC). Although one prominent view links PrC processes with familiarity-based memory and PhC with recollection, an alternative organizing principle is the representational domain critical for successful memory performance (e.g., object- versus scene-related information). In this functional magnetic resonance imaging study, we directly compared successful source encoding during object versus scene imagery, holding perceptual input constant across the two representational domains. Although the hippocampus contributed to associative encoding of both object and scene information, our results revealed a clear double dissociation between PrC and PhC for object- versus scene-related source encoding. In particular, PrC, but not PhC, encoding activation predicted later source memory for the object imagery task, whereas PhC, but not PrC, encoding activation predicted later source memory for the scene imagery task. Interestingly, the transitional zone between PrC and posterior PhC contributed to both object and scene source encoding, possibly reflecting a gradient in domain preference along MTLC. In sum, these results strongly point to representational domain as a key factor determining the involvement of different MTLC subregions during successful episodic memory formation.Keywords
This publication has 55 references indexed in Scilit:
- Mind the Gap: Binding Experiences across Space and Time in the Human HippocampusNeuron, 2009
- Category‐specificity in the human medial temporal lobe cortexHippocampus, 2008
- Comparison of Associative Learning-Related Signals in the Macaque Perirhinal Cortex and HippocampusCerebral Cortex, 2008
- Selective and Shared Contributions of the Hippocampus and Perirhinal Cortex to Episodic Item and Associative EncodingJournal of Cognitive Neuroscience, 2008
- Content-specific source encoding in the human medial temporal lobe.Journal of Experimental Psychology: Learning, Memory, and Cognition, 2008
- Recognition memory and the medial temporal lobe: a new perspectiveNature Reviews Neuroscience, 2007
- The Medial Temporal Lobe and Recognition MemoryAnnual Review of Neuroscience, 2007
- Episodic Encoding Is More than the Sum of Its Parts: An fMRI Investigation of Multifeatural Contextual EncodingNeuron, 2006
- Item memory, source memory, and the medial temporal lobe: Concordant findings from fMRI and memory-impaired patientsProceedings of the National Academy of Sciences of the United States of America, 2006
- Recognition memory: What are the roles of the perirhinal cortex and hippocampus?Nature Reviews Neuroscience, 2001