Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis
- 2 July 2009
- journal article
- review article
- Published by Zhejiang University Press in Journal of Zhejiang University-SCIENCE B
- Vol. 10 (7), 493-498
- https://doi.org/10.1631/jzus.b0820265
Abstract
During the development and progression of severe acute pancreatitis (SAP), conspicuous immune dysregulation develops, which is mainly manifested as excessive immune response in the early stage and immunosuppression in the late stage. This process involves complex changes in a variety of immune molecules and cells, such as cytokines, complements, lymphocytes, and leukocytes. With the gradual deepening of studies on the development and progression of SAP, the role of immune dysregulation in the pathogenesis of SAP has attracted more and more attention. In this article, we review the advances in research on the immune dysregulation in SAP and the immunotherapy of this disease through exploring the formation of excessive immune response and immune suppression as well as their mutual transformation.Keywords
This publication has 34 references indexed in Scilit:
- New advances in acute pancreatitisCurrent Opinion in HIV and AIDS, 2007
- Thymosin alpha 1 improves severe acute pancreatitis in rats via regulation of peripheral T cell number and cytokine serum levelJournal of Gastroenterology and Hepatology, 2007
- Interaction of complement and leukocytes in severe acute pancreatitis: potential for therapeutic interventionAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2006
- Protective Effects of Ulinastatin on Proliferation and Cytokine Release of Splenocytes from Rats with Severe Acute PancreatitisEuropean Surgical Research, 2006
- Immunosuppression in patients with severe acute pancreatitisThe Esophagus, 2006
- Effects of Immunosuppressive and Immunostimulative Treatment on Pancreatic Injury and Mortality in Severe Acute Experimental PancreatitisPancreas, 2006
- Monocyte Anergy Is Present in Patients With Severe Acute Pancreatitis and Is Significantly Alleviated by Granulocyte-Macrophage Colony-stimulating Factor and Interferon-?? In VitroPancreas, 2005
- Cytokines (IL-6, IL-8, TNF)Journal of Clinical Gastroenterology, 2003
- T-cell subsets (Th1 versus Th2)Annals of Allergy, Asthma & Immunology, 2000
- Activation of the Complement Cascade by TrypsinBiological Chemistry Hoppe-Seyler, 1991